VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene, the rs2228570 (FokI polymorphism), is associated with a decrease in bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time occupancy of the VDRE between the two components. It is also modulated by chromosomal locations and binding preferences for certain hormones. Microarray studies of human cells indicate that more than 100 genes possess a recognizable VDRE in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for information and documents related to legal, business transactions or proceedings that are restricted in viewing or downloading. It makes use of a central computer and an extranet, which is a restricted-access Internet connection, allowing users gescheftmarketing.de/2021/12/29/gaining-knowledge-and-business-direction-2/ to access the internet at specific times.
VDRs are primarily used by investment banks and businesses involved in mergers or acquisitions. They need to be able to share information in a transparent manner with potential investors or buyers. The due diligence process will also require a significant amount of information. Life science companies also use VDRs to keep everything from clinical trial results to HIPAA documentation.